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STAT5-IN-1

Cat. No. M9077
STAT5-IN-1 Structure
Synonym:

STAT5 Inhibitor

Size Price Availability Quantity
10mg USD 110 In stock
25mg USD 235 In stock
50mg USD 420 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

STAT5-IN-1 is a cell permeable nonpetidic nicotinoyl hydrazone which suppresses Stat5 via binding to the SH2 domain, with an IC50 of 47 μM for STAT5β isoform. STAT5-IN-1 block STAT5/STAT5 DNA binding in K562 nuclear extracts.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 293.28
Formula C16H11N3O3
CAS Number 285986-31-4
Purity >98%
Solubility DMSO: ≥ 20 mg/mL
Storage at -20°C
References

Discovery of chromone-based inhibitors of the transcription factor STAT5.
Muller J, et al. Chembiochem. 2008 Mar 25;9(5):723-7. PMID: 18247434.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: STAT5-IN-1, STAT5 Inhibitor supplier, STAT, inhibitors

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