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STAT3-IN-3

Cat. No. M14149
STAT3-IN-3 Structure
Size Price Availability
5mg USD 350  USD350 1-2 Weeks
10mg USD 550  USD550 1-2 Weeks
25mg USD 1100  USD1100 1-2 Weeks
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Quality Control & Documentation
Biological Activity

STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3), with anti-proliferative activity. STAT3-IN-3 induces apoptosis in breast cancer cells. STAT3-IN-3 acts as a promising mitochondria-targeting STAT3 inhibitor for cancer research.

Chemical Information
Molecular Weight 600.48
CAS Number 2361304-26-7
Solubility (25°C) DMSO 5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yancai Liu, et al. Biol Pharm Bull. MicroRNA-221 Upregulates the Expression of P-gp and Bcl-2 by Activating the Stat3 Pathway to Promote Doxorubicin Resistance in Osteosarcoma Cells

Related STAT Products
STAT3-IN-21, cell-permeable, negative control

STAT3-IN-21, cell-permeable, negative control, a peptide, is a negative control for Stat3 activity detection.

STAT3-IN-24, cell-permeable

STAT3-IN-24, cell-permeable (PpYLKTK-mts) is a STAT3 peptide inhibitor.

5-FAM-GpYLPQTV-NH2

5-FAM-GpYLPQTV-NH2 is a fluorescently labeled peptide and has STAT3 inhibitory activity.

Ac-GpYLPQTV-NH2

Ac-GpYLPQTV-NH2 is a STAT3 inhibitor with an IC50 value of 0.33 μM.

XZH-5

XZH-5 inhibits the phosphorylation of STAT3 and results in the induction of apoptosis and reduction of colony forming ability.

  Catalog
Abmole Inhibitor Catalog




Keywords: STAT3-IN-3 supplier, STAT, inhibitors, activators


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