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ST 271

Cat. No. M20582
ST 271 Structure
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Biological Activity

ST271 is a tyrphostin-like protein tyrosine kinase (PTK) inhibitor which inhibits phospholipase D (PLD) activity.

Chemical Information
Molecular Weight 272.34
Formula C16H20N2O2
CAS Number 106392-48-7
Solubility (25°C) DMSO 54 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] M Hjlmarsdttir, et al. J Antimicrob Chemother. Epidemiology of penicillin-non-susceptible pneumococci in Iceland, 1995-2010

[2] R Ohno. Gan To Kagaku Ryoho. [Tyrosine kinase inhibitor--hematological malignancies]

[3] T R Pettitt, et al. Biochem J. Epidermal growth factor stimulates distinct diradylglycerol species generation in Swiss 3T3 fibroblasts: evidence for a potential phosphatidylcholine-specific phospholipase C-catalysed pathway

[4] B Rodrguez-Liares, et al. FEBS Lett. Phosphorylation of JAK2 in thrombin-stimulated human platelets

[5] T Shiraishi, et al. Cancer Res. Specific inhibitors of tyrosine-specific protein kinases: properties of 4-hydroxycinnamamide derivatives in vitro

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Keywords: ST 271 supplier, Phospholipase, inhibitors, activators


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