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SST0287CL1

Cat. No. M3432
SST0287CL1 Structure
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

SST0287CL1 is a potent, small molecule Heat Shock Protein 90 (HSP90) inhibitor. SST0287CL1 is more active than NVP-AUY922. SST0287CL1 was selected for further investigation as the most promising compound candidate.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 465.54
Formula C25H31N5O4
CAS Number
Purity >99%
Solubility DMSO
Storage at -20°C
References

Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold.
Taddei M, et al. J Med Chem. 2014 Mar 27;57(6):2258-74. PMID: 24588105.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SST0287CL1 supplier, HSP90, inhibitors

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