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SSR240612

Cat. No. M7534
SSR240612 Structure
Size Price Availability Quantity
10mg USD 330  USD330 In stock
25mg USD 660  USD660 In stock
50mg USD 1000  USD1000 In stock
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Quality Control & Documentation
Biological Activity

Treatment with the kinin B1 receptor antagonist, SSR240612, provided a protective effect against organ damage by interfering with multiple target functions, including the suppression of B1R-induced inflammation and platelet aggregation.

Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models C57BL/6J mice
Formulation
Dosages 10 mg/kg
Administration gavage
Chemical Information
Molecular Weight 793.41
Formula C42H53ClN4O7S
CAS Number 464930-42-5
Form Solid
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] El Akoum S, et al. Obes Sci Pract. Impact of pioglitazone and bradykinin type 1 receptor antagonist on type 2 diabetes in high-fat diet-fed C57BL/6J mice.

[2] Tidjane N, et al. Eur J Inflamm. A primary role for kinin B1 receptor in inflammation, organ damage, and lethal thrombosis in a rat model of septic shock in diabetes.

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  Catalog
Abmole Inhibitor Catalog




Keywords: SSR240612 supplier, Bradykinin Receptor, inhibitors, activators


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