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SSR128129E

Cat. No. M3031

SSR128129E Structure

Synonym: SSR

Size Price Availability Quantity
5mg USD 70 In stock
10mg USD 110 In stock
50mg USD 350 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

SSR128129E is an orally-active and allosteric FGFR1 inhibitor with IC50 of 1.9 μM, while not affecting other related RTKs.

Protocol
Cell Experiment
Cell lines Endothelial cells (ECs) and Panc02 tumor cells
Preparation method Cell proliferation of porcine aortic endothelial (PAE) and tumor cell lines is analyzed on exponentially growing cells that are starved for 16 hours in 0.2 % FBS containing medium and seeded at 4,000 cells/well in 96-well microplates. After exposure to mitogens and/or SSR for 72 hours, according to manufacturer’s instructions, assessing the cell proliferation with the use of the CellTiter 96 AQueous One Solution Cell Proliferation Assay . 10 % FBS containing medium is used a positive control
Concentrations ~100 nM
Incubation time 72 hours
Animal Experiment
Animal models Mouse model of Arthritic and mouse tumor model bearing pancreatic tumor cell line Panc02, murine mammary carcinoma cell line 4T1, murine colon cancer cell line CT26, or human breast MCF7/ADR cell line.
Formulation 0.6 % methylcellulose
Dosages ~30 mg/kg
Administration Oral administration
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 346.31
Formula C18H15N2O4.Na
CAS Number 848318-25-2
Purity >99%
Solubility DMSO 50 mg/mL
Storage at -20°C
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BLU-9931

BLU9931 is a potent, selective, and irreversible FGFR4 inhibitor with IC50 of 3 nM, about 297-, 184-, and 50-fold selectivity over FGFR1/2/3, respectively.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SSR128129E, SSR supplier, FGFR, inhibitors

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