SRT2104 is a selective brain-permeable activator of SIRT1. SRT2104 (3 μM) reduces p65/RelA acetylation levels in C2C12 cells.
In vivo, SRT2104 (100 mg/kg, p.o.) improves whole-body physiology and extends lifespan in mice fed a standard diet. SRT2104 increases mitochondrial content and suppresses the inflammatory response in SD-fed mice. In Male N171-82Q HD mice, SRT2104 (diet containing 0.5% SRT2104) effectively penetrates the blood-brain barrier, attenuates brain atrophy, improves motor function, and extends survival.
Molecular Weight | 516.64 |
Formula | C26H24N6O2S2 |
CAS Number | 1093403-33-8 |
Solubility (25°C) | DMSO: 5 mg/mL (Need ultrasonic and warming) |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Fuzhe Ma, et al. P53/NRF2 mediates SIRT1's protective effect on diabetic nephropathy
[5] Jos M Villalba, et al. Sirtuin activators and inhibitors
Related Sirtuin Products |
---|
ADTL-SA1215
ADTL-SA1215 is a first-in-class, specific small molecule activator of SIRT3 that modulates autophagy in triple-negative breast cancer. |
SIRT2/6-IN-1
SIRT2/6-IN-1 is a SIRT6/SIRT2 inhibitor, with IC50s of 106 μM and 114 μM. |
SIRT6-IN-2
SIRT6-IN-2 is a selective SIRT6 inhibitor (IC50: 34 μM). |
SIRT6-IN-3
SIRT6-IN-3 is a selective inhibitor of SIRT6 (IC50=7.49 μM). |
Z26395438
Z26395438 is a potent Sirtuin-1 inhibitor, with an IC50 value of 1.6 μM. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.