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SRT2104

Cat. No. M9148
SRT2104 Structure
Synonym:

GSK2245840

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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

SRT2104 is a selective brain-permeable activator of SIRT1. SRT2104 (3 μM) reduces p65/RelA acetylation levels in C2C12 cells. 

In vivo, SRT2104 (100 mg/kg, p.o.) improves whole-body physiology and extends lifespan in mice fed a standard diet. SRT2104 increases mitochondrial content and suppresses the inflammatory response in SD-fed mice. In Male N171-82Q HD mice, SRT2104 (diet containing 0.5% SRT2104) effectively penetrates the blood-brain barrier, attenuates brain atrophy, improves motor function, and extends survival.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 516.64
Formula C26H24N6O2S2
CAS Number 1093403-33-8
Purity >98%
Solubility DMSO: 8 mg/mL (Need ultrasonic and warming)
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SRT2104, GSK2245840 supplier, Sirtuin, inhibitors

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