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Cat. No. M3028
Spironolactone Structure

SC9420; Abbolactone

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 45  USD45 In stock
500mg USD 55  USD55 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Spironolactone (SC9420) is an oral active aldosterone mineralocorticoid receptor antagonist with an IC50 value of 24 nM. Spironolactone is also an androgen receptor antagonist with an IC50 of 77 nM. Spironolactone promotes podocyte autophagy.

Cell Experiment
Cell lines
Preparation method
Incubation time
Animal Experiment
Animal models Rats
Dosages 0-1 mg/day
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 416.57
Formula C24H32O4S
CAS Number 52-01-7
Purity >99%
Solubility DMSO ≥ 40 mg/mL
Storage at -20°C

[1] Laura Carone, et al. Spironolactone

[2] Mitja Lainscak, et al. Safety profile of mineralocorticoid receptor antagonists: Spironolactone and eplerenone

[3] Josh Batterink, et al. Spironolactone for hypertension

[4] Allan Struthers, et al. A comparison of the aldosterone-blocking agents eplerenone and spironolactone

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Keywords: Spironolactone, SC9420; Abbolactone supplier, Mineralocorticoid Receptor, inhibitors

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