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(-)-Sparteine Sulfate

Cat. No. M20507
(-)-Sparteine Sulfate Structure
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Biological Activity

Sparteine Sulfate, a quinolizidine alkaloid, is the sulfate form of sparteini, which is a sodium channel blocker used as an oxytocic and an anti-arrhythmia agent.

Chemical Information
Molecular Weight 422.54
Formula C15H38N2O9S
CAS Number 6160-12-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Manuel Hidalgo, et al. Rev Peru Med Exp Salud Publica. Evaluation of in vitro susceptibility to sparteine in four strains of Mycobacterium tuberculosis

[2] Fridha Villalpando-Vargas, et al. Seizure. Sparteine as an anticonvulsant drug: Evidence and possible mechanism of action

[3] A A PLENTL, et al. Am J Obstet Gynecol. Sparteine sulfate; a clinical evaluation of its use for the induction of labor

[4] W F Peterson. Med Times. Sparteine sulfate--a reappraisal

[5] B W Newton, et al. Am J Obstet Gynecol. Sparteine sulfate: a potent, capricious oxytocic

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Keywords: (-)-Sparteine Sulfate supplier, Sodium Channel, inhibitors, activators


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