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Sodium succinate

Cat. No. M9171
Sodium succinate Structure
Synonym:

Disodium butanedioate

Size Price Availability Quantity
10g USD 40  USD40 In stock
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Quality Control & Documentation
Biological Activity

Sodium succinate is the sodium salt form of succinate, which is an important metabolite at the cross-road of several metabolic pathways and involved in the formation and elimination of reactive oxygen species.

Chemical Information
Molecular Weight 162.05
Formula C4H4Na2O4
CAS Number 150-90-3
Solubility (25°C) Water 32 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Lena Schleicher, et al. A Sodium-Translocating Module Linking Succinate Production to Formation of Membrane Potential in Prevotella bryantii

[2] Zhen-Feng Huang, et al. Sodium starch octenyl succinate facilitated the production of water-soluble yellow pigments in Monascus ruber fermentation

[3] Moran Fremder, et al. A transepithelial pathway delivers succinate to macrophages, thus perpetuating their pro-inflammatory metabolic state

[4] Chanjuan Lai, et al. Effects of different alcohol and ultrasonic treatments on thermal and structural properties of zein-starch sodium octenyl succinate composite nanoparticles

[5] Lakshini Y Herat, et al. Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice

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Keywords: Sodium succinate, Disodium butanedioate supplier, inhibitors, activators


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