Free shipping on all orders over $ 500

Sodium Stibogluconate

Cat. No. M9081
Sodium Stibogluconate Structure
Synonym:

Stibogluconate sodium

Size Price Availability
500mg USD 70 Custom Synthesis
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Sodium Stibogluconate inhibits 99% of SHP-1, SHP-2 and PTP1B activity at 10, 100, 100 μg/mL, respectively. The augmentation of the opposite effects of GM-CSF and IFN-α on TF-1 cell growth by Stibogluconate sodium indicate its broad activities in the signaling of various cytokines. Stibogluconate sodium induces 61% growth inhibition of Renca tumors in BALB/c mice coincident with an increase (2-fold) in tumor-infiltrating macrophages.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 917.96
Formula C12H45Na3O26Sb2
CAS Number 16037-91-5
Purity >98%
Solubility Water ≥ 6 mg/mL (Need warming)
Storage at -20°C
References

Sodium stibogluconate interacts with IL-2 in anti-Renca tumor action via a T cell-dependent mechanism in connection with induction of tumor-infiltrating macrophages.
Fan K, et al. J Immunol. 2005 Nov 15;175(10):7003-8. PMID: 16272361.

Sodium stibogluconate is a potent inhibitor of protein tyrosine phosphatases and augments cytokine responses in hemopoietic cell lines.
Pathak MK, et al. J Immunol. 2001 Sep 15;167(6):3391-7. PMID: 11544330.

Related Products
S107

S107 is a Type 1 ryanodine receptor (RyR1) stabilizer.

TMB

3,3’,5,5’-Tetramethylbenzidine(TMB) is a chromogenic substrate used in staining procedures in immunohistochemistry as well as being a visualising reagent used in enzyme-linked immunosorbent assays (ELISA).

Coelenterazine

Coelenterazine is the luciferin, the light-emitting molecule, used for monitoring reporter genes in BRET, ELISA and HTS techniques.

Fluorescein

Fluorescein is a synthetic organic compound and dye.

SBI-0640756

SBI-0640756 is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Sodium Stibogluconate, Stibogluconate sodium supplier, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.