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Sodium-Danshensu

Cat. No. M4146
Sodium-Danshensu Structure
Synonym:

Sodium Danshensu; (±)-DanShenSu sodium sal

Size Price Availability Quantity
10mg USD 50  USD50 In stock
20mg USD 75  USD75 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Danshensu (sodium) is the active component of salvia miltiorrhiza, which can inhibit the formation of reactive oxygen species, inhibit platelet adhesion and aggregation, and protect myocardial ischemia.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 220.16
Formula C9H9NaO5
CAS Number 67920-52-9
Purity >98%
Solubility Water 60 mg/mL
DMSO 60 mg/mL
Storage at -20°C
References

[1] Qiong-Zhi Zhang, et al. Sodium Danshensu promotes the healing of stage 2 pressure injury wounds in ischemia/reperfusion injury rat models: possible regulation of apoptosis and inflammatory response

[2] Miao Wang, et al. Sodium Danshensu inhibits the progression of lung cancer by regulating PI3K/Akt signaling pathway

[3] V Bharath Kumar, et al. Sodium Danshensu Inhibits Oral Cancer Cell Migration and Invasion by Modulating p38 Signaling Pathway

[4] Xiangguo Meng, et al. Preclinical Absorption, Distribution, Metabolism, and Excretion of Sodium Danshensu, One of the Main Water-Soluble Ingredients in Salvia miltiorrhiza, in Rats

[5] Ning Zhang, et al. Biphasic effects of sodium danshensu on vessel function in isolated rat aorta

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Keywords: Sodium-Danshensu, Sodium Danshensu; (±)-DanShenSu sodium sal supplier, Cytochrome P450 (e.g. CYP17), inhibitors
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