SAG regulates Smo activity by binding directly to the Smo heptahelical bundle. SAG also (1 nM) induces proliferation of neuronal and glial precursors without affecting the differentiation pattern of newly produced cells.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 71 mg/mL
Water 100 mg/mL
Small molecule modulation of Smoothened activity.
Chen JK, et.al. Proc Natl Acad Sci U S A. 2002 Oct;29;99(22). PMID: 12391318.
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