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Smoothened Agonist (SAG) HCl

Cat. No. M4865
Smoothened Agonist (SAG) HCl Structure
Synonym:

SAG.HCl

Size Price Availability Quantity
5mg USD 220 In stock
10mg USD 400 In stock
25mg USD 650 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

SAG regulates Smo activity by binding directly to the Smo heptahelical bundle. SAG also (1 nM) induces proliferation of neuronal and glial precursors without affecting the differentiation pattern of newly produced cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 526.52
Formula C28H29Cl2N3OS
CAS Number 912545-86-9(free base)
Purity >99%
Solubility DMSO 71 mg/mL
Water 100 mg/mL
Storage at -20°C
References

Small molecule modulation of Smoothened activity.
Chen JK, et.al. Proc Natl Acad Sci U S A. 2002 Oct;29;99(22). PMID: 12391318.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Smoothened Agonist (SAG) HCl, SAG.HCl supplier, Hedgehog, inhibitors

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