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SMI-4a

Cat. No. M2572
SMI-4a Structure
Synonym:

TCS PIM-1 4a

Size Price Availability Quantity
10mg USD 110 In stock
50mg USD 360 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

SMI-4a is a potent inhibitor of Pim1 with IC50 of 17 nM, modest potent to Pim-2, does not significantly inhibit other serine/threonine- or tyrosine-kinases.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 273.23
Formula C11H6F3NO2S
CAS Number 438190-29-5
Purity >99%
Solubility DMSO 50 mg/mL
Storage at -20°C
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AZD-1208

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SMI-4a, TCS PIM-1 4a supplier, Pim, inhibitors

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