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SMER 28

Cat. No. M7546
SMER 28 Structure
Size Price Availability Quantity
10mg USD 90 In stock
50mg USD 330 In stock
100mg USD 650 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

SMER28 is an autophagy activator acting via an mTOR-independent mechanism. SMER28 prevents the accumulation of amyloid beta peptide.

Protocol
Cell Experiment
Cell lines Mouse embryonic fibroblast (MEF) cells
Preparation method Cell lysates were analyzed by SDS-PAGE and Western blotting using anti-βCTF (6E10) and anti-tubulin antibodies. B, C) N2a-APP cells were treated with increasing concentrations of SMER28 for 16 h (B) or with a fixed concentration of SMER28 (50 μM) for various periods of time
Concentrations 50 μM
Incubation time 16 h
Animal Experiment
Animal models
Formulation
Dosages
Administration
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 264.12
Formula C11H10BrN3
CAS Number 307538-42-7
Purity >98%
Solubility 32 mg/mL in DMSO
Storage at -20°C
References

A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway.
Tian Y, et al. FASEB J. 2011 Jun;25(6):1934-42. PMID: 21368103.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SMER 28 supplier, Autophagy, inhibitors

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