SMER28 is an autophagy activator acting via an mTOR-independent mechanism. SMER28 prevents the accumulation of amyloid beta peptide.
|Cell lines||Mouse embryonic fibroblast (MEF) cells|
|Preparation method||Cell lysates were analyzed by SDS-PAGE and Western blotting using anti-βCTF (6E10) and anti-tubulin antibodies. B, C) N2a-APP cells were treated with increasing concentrations of SMER28 for 16 h (B) or with a fixed concentration of SMER28 (50 μM) for various periods of time|
|Incubation time||16 h|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||32 mg/mL in DMSO|
A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway.
Tian Y, et al. FASEB J. 2011 Jun;25(6):1934-42. PMID: 21368103.
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