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SKLB1002

Cat. No. M3013
SKLB1002 Structure
Size Price Availability Quantity
10mg USD 160 In stock
50mg USD 550 In stock
100mg USD 1090 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

SKLB1002 is a potent and ATP-competitive VEGFR2 inhibitor with IC50 of 32 nM.

Protocol
Cell Experiment
Cell lines HUVECs, L-02, B16-F10, HepG2, and SW620 cells.
Preparation method Cell proliferation Using MTT assay to measure cell proliferation . Various cells including HUVECs, L-02, B16-F10, HepG2, and SW620 are treated with indicated concentrations of SKLB1002 for 24 hours. Vandetanib and sunitinib serve as positive controls. Each assay is replicated 3 times.
Concentrations ~40 μM
Incubation time 24 hours
Animal Experiment
Animal models Mice bearing SW620 or HepG2 tumors
Formulation 35% (v/v) polyethylene glycol solution containing 5% (v/v) DMSO
Dosages ~100 mg/kg daily
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 320.39
Formula C13H12N4O2S2
CAS Number 1225451-84-2
Purity >99%
Solubility DMSO
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SKLB1002 supplier, VEGFR/PDGFR, inhibitors

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