Free shipping on all orders over $ 500

Sinefungin

Cat. No. M8196
Sinefungin Structure
Synonym:

Adenosyl-Ornithine

Size Price Availability
1mg USD 300  USD300 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Sinefungin blocks the methylation of bases in DNA and RNA, such as 5-methylcytosine or N6-methyladenosine, suggesting a role in gene expression. In addition, sinefugin is involved in physiological processes such as aging and carcinogenesis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 381.39
Formula C15H23N7O5
CAS Number 58944-73-3
Purity >98%
Solubility Water ≥ 40 mg/mL
Storage -20°C, protect from light, dry, sealed
Related Histone Methyltransferase Products
Tazemetostat hydrobromide

Tazemetostat (EPZ-6438) hydrobromide is a potent, selective and orally available EZH2 inhibitor.

PFI-2 hydrochloride

PFI-2 hydrochloride is a potent, highly selective and cell-active inhibitor of the methyltransferase activity of SETD7, with IC50 of 2 nM.

CM-272

CM-272 is a first-in-class reversible dual small molecule inhibitor against G9a and DNMTs in hematological malignancies.

MI-503

MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM.

MI-463

MI-463 is a highly potent and orally bioavailable small molecule inhibitor of the Menin-MLL interaction, with an IC50 value of 15.3 nM.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Sinefungin, Adenosyl-Ornithine supplier, Histone Methyltransferase, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.