In vitro: sinapine plays an important role in the downregulation of MDR1 expression through suppression of fibroblast growth factor receptor (FGFR)4/FRS2α-ERK1/2 mediated NF-κB activation in MCF-7/dox cancer cells. sinapine can effectively protect against ·OH-induced damage to DNA and MSCs. Sinapine promotes doxorubicin accumulation in Caco-2 cell by inducing P-gp decrease. Sinapine significantly reduces phosphorylation of FRS2α, ERK1/2. Sinapine sensitive effects may occur through the suppression FGFR4-FRS2α-ERK1/2 signal pathway.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||10 mM in DMSO|
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