Free shipping on all orders over $ 500
In vitro: sinapine plays an important role in the downregulation of MDR1 expression through suppression of fibroblast growth factor receptor (FGFR)4/FRS2α-ERK1/2 mediated NF-κB activation in MCF-7/dox cancer cells. sinapine can effectively protect against ·OH-induced damage to DNA and MSCs. Sinapine promotes doxorubicin accumulation in Caco-2 cell by inducing P-gp decrease. Sinapine significantly reduces phosphorylation of FRS2α, ERK1/2. Sinapine sensitive effects may occur through the suppression FGFR4-FRS2α-ERK1/2 signal pathway.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
| Molecular Weight | 368.45 |
| Formula | C17H24N2O5S |
| CAS Number | 7431-77-8 |
| Purity | >98% |
| Solubility | 10 mM in DMSO |
| Storage | at -20°C |
| Related P-gp Products |
|---|
| Valspodar
Valspodar is a P-glycoprotein (P-gp) inhibitor widely used as overcoming multidrug resistance modulator. |
| Elacridar (GF120918)
Elacridar (GF120918) is a potent P-gp (MDR-1) and BCRP inhibitor. |
| Polyoxyethylene stearate
Polyoxyethylene stearate (POES) is a non-ionic emulsifying agent. |
| Tariquidar
Tariquidar (XR9576) is a selective, highly efficacious third generation P-glycoprotein (P-gp) inhibitor. |
| Biricodar
The pipecolinate derivative Biricodar (VX-710, Incel) is a clinically applicable modulator of P-glycoprotein (Pgp) with potential chemosensitizing activity. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.
