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Sinapine-thiocyanate

Cat. No. M4792
Sinapine-thiocyanate Structure
Size Price Availability Quantity
20mg USD 150 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

In vitro: sinapine plays an important role in the downregulation of MDR1 expression through suppression of fibroblast growth factor receptor (FGFR)4/FRS2α-ERK1/2 mediated NF-κB activation in MCF-7/dox cancer cells. sinapine can effectively protect against ·OH-induced damage to DNA and MSCs. Sinapine promotes doxorubicin accumulation in Caco-2 cell by inducing P-gp decrease. Sinapine significantly reduces phosphorylation of FRS2α, ERK1/2. Sinapine sensitive effects may occur through the suppression FGFR4-FRS2α-ERK1/2 signal pathway.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 368.45
Formula C17H24N2O5S
CAS Number 7431-77-8
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Sinapine-thiocyanate supplier, P-gp, inhibitors

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