Free shipping on all orders over $ 500

Silodosin

Cat. No. M3551
Silodosin Structure
Synonym:

KAD 3213; KMD 3213

Size Price Availability Quantity
10mg USD 60  USD60 In stock
50mg USD 120  USD120 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Silodosin (Rapaflo) is an α1-adrenoceptor antagonist with high uroselectivity. It causes practically no orthostatic hypotension (in contrast to other α1 blockers). Since Silodosin is a highly selective inhibitor of the α1A adrenergic receptor, it causes practically no orthostatic hypotension (in contrast to other α1 blockers). On the other hand, the high selectivity seems to cause more problems with ejaculation.

Chemical Information
Molecular Weight 495.53
Formula C25H32F3N3O4
CAS Number 160970-54-7
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Gianluigi Califano, et al. Focus on Silodosin: Pros and Cons of Uroselectivity

[2] No authors listed. Silodosin

[3] Luca Villa, et al. Silodosin: An Update on Efficacy, Safety and Clinical Indications in Urology

[4] No authors listed. Aust Prescr. Silodosin for benign prostatic hypertrophy

[5] R Manjunatha, et al. A randomized, comparative, open-label study of efficacy and tolerability of alfuzosin, tamsulosin and silodosin in benign prostatic hyperplasia

Related Adrenergic Receptor Products
(Des-His6)-ACTH (1-24) (human, bovine, rat)

(Des-His6)-ACTH (1-24) (human, bovine, rat) is an analogue of Adrenocorticotropic hormone (ACTH).

ACTH (1-14)

ACTH (1-14) is a fragment of adrenocorticotrophin, which regulates cortisol and androgen production.

Mibenratide

Mibenratide, a small cyclic peptide, is an adrenergic β1 receptor antagonist.

Conopeptide rho-TIA

Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human α1B-Adrenergic Receptor.

Muscarinic toxin 3

Muscarinic toxin 3 (MT3) is a potent and non-competitive mAChR and adrenoceptors antagonist with pIC50s of 6.71, 8.79, 8.86, 7.57, 8.13, 8.49, <6.5, 7.29 against M1, M4, α1A, α1B, α1D,α2A,α2B and α2C receptors, respectively.

  Catalog
Abmole Inhibitor Catalog




Keywords: Silodosin, KAD 3213; KMD 3213 supplier, Adrenergic Receptor, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.