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Sildenafil

Cat. No. M5959

Sildenafil  Structure

Synonym: Revatio, UK-92480, Viagra

Size Price Availability Quantity
25mg USD 70 In stock
50mg USD 110 In stock
100mg USD 200 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Sildenafil is a Phosphodiesterase 5 Inhibitor with IC50 of 5.22 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 474.58
Formula C22H30N6O4S
CAS Number 139755-83-2
Purity >99%
Solubility 14 mg/mL in water
Storage at -20°C
References

Sildenafil in pediatric pulmonary arterial hypertension.
Dhariwal AK, et al. J Postgrad Med. 2015 Jul-Sep;61(3):181-92. PMID: 26119438.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Sildenafil , Revatio, UK-92480, Viagra supplier, PDE, inhibitors

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