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Sildenafil citrate

Cat. No. M2286

Sildenafil citrate Structure

Synonym: Viagra, Revatio

Size Price Availability Quantity
25mg USD 60 In stock
50mg USD 90 In stock
100mg USD 130 In stock
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Quality Control
Biological Activity

Sildenafil citrate is an agent used to treat erectile dysfunction and pulmonary arterial hypertension (PAH). Sildenafil citrate acts by inhibiting cGMP specific phosphodiesterase type 5, an enzyme that regulates blood flow in the penis. Sildenafil has been the prime treatment for erectile dysfunction.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 666.7
Formula C22H30N6O4S.C6H8O7
CAS Number 171599-83-0
Purity 100.00%
Solubility DMSO 20 mg/mL
Storage at -20°C
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Sildenafil Mesylate

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Sildenafil citrate, Viagra, Revatio supplier, PDE, inhibitors

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