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Shikimic acid

Cat. No. M10651
Shikimic acid Structure
Size Price Availability Quantity
50mg USD 40  USD40 In stock
100mg USD 50  USD50 In stock
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Quality Control & Documentation
Biological Activity

Shikimic acid is an important metabolic intermediate with various applications. Shikimic acid is an industrially important compound that acts as a precursor in the synthesis of many chemical substances like oseltamivir phosphate.

Chemical Information
Molecular Weight 174.15
Formula C7H10O5
CAS Number 138-59-0
Solubility (25°C) Water 100 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mirella Batory, et al. J Cosmet Dermatol. Shikimic acid in the light of current knowledge

[2] Garima Rawat, et al. Appl Microbiol Biotechnol. Expanding horizons of shikimic acid. Recent progresses in production and its endless frontiers in application and market trends

[3] Amalia M Estvez, et al. Mini Rev Med Chem. A short overview on the medicinal chemistry of (-)-shikimic acid

[4] Saptarshi Ghosh, et al. Biotechnol Adv. Production of shikimic acid

[5] B Stavric, et al. Food Cosmet Toxicol. Shikimic acid

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