Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP.
Molecular Weight | 748.9 |
Formula | C42H56N2O10 |
CAS Number | 914805-33-7 |
Solubility (25°C) | DMSO ≥ 100 mg/mL (ultrasonic and warming) |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Related FKBP (FK506-binding protein) Products |
---|
Suc-Ala-Leu-Pro-Phe-pNA
Suc-Ala-Leu-Pro-Phe-pNA (Suc-ALPF-pNA) is a substrate of FK-506 binding protein (FKBP). |
RapaBlock
RapaBlock is a potent, non-immunosuppressive and brain-impermeable FKBP12 ligand. |
FKBP51F67V-selective antagonist Ligand2
FKBP51F67V-selective antagonist Ligand2 is a potent FKBP51 F67V-selective antagonist ligand. |
dTAGV-1-NEG TFA
dTAGV-1-NEG TFA is a diastereomer and as a heterobifunctional negative control of dTAGV-1. dTAGV-1-NEG TFA is an FKBP12F36V-selective degrader. |
AP1867
AP1867 is a synthetic FKBP12F36V-directed ligand. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.