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Shield-1

Cat. No. M9704
Shield-1 Structure
Synonym:

AquaShield-1; Shld1

Size Price Availability Quantity
1mg USD 180  USD180 In stock
5mg USD 410  USD410 In stock
10mg USD 680  USD680 In stock
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Quality Control & Documentation
Biological Activity

Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP.

Chemical Information
Molecular Weight 748.9
Formula C42H56N2O10
CAS Number 914805-33-7
Solubility (25°C) DMSO ≥ 100 mg/mL (ultrasonic and warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shuying Li, et al. Mol Med Rep. Effects of Shield1 on the viral replication of varicella‑zoster virus containing FKBP‑tagged ORF4 and 48

[2] Joost P H Schoeber, et al. Am J Physiol Renal Physiol. Conditional fast expression and function of multimeric TRPV5 channels using Shield-1

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  Catalog
Abmole Inhibitor Catalog




Keywords: Shield-1, AquaShield-1; Shld1 supplier, FKBP (FK506-binding protein), inhibitors, activators


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