Free shipping on all orders over $ 500

TRP-14

Cat. No. M9857
TRP-14 Structure
Synonym:

TRAP; SFLLRNPNDKYEPF; ThroMbin Receptor Agonist Peptide

Size Price Availability Quantity
1mg USD 90  USD90 In stock
5mg USD 265  USD265 In stock
25mg USD 820  USD820 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe is a synthetic thrombin receptor agonist peptide. SFLLRNPNDKYEPF activates and induces platelet aggregation and serotonin secretion. TRAP induces rapid morphological changes in HUVECs, with marked increase in the release of prostacyclin, endothelin, platelet activating factor, tissue type plasminogen activator, and plasminogen activator inhibitor-1. Incubation of cells with TRAP also induces a rapid decrease in cell-surface thrombomodulin.

Chemical Information
Molecular Weight 1739.92
Formula C81H118N20O23
CAS Number 137339-65-2
Solubility (25°C) Water 40 mg/mL
DMSO 70 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Y Maruyama, et al. Biochem Biophys Res Commun. Thrombin receptor agonist peptide decreases thrombomodulin activity in cultured human umbilical vein endothelial cells

[2] Y Sugama, et al. Circ Res. Thrombin receptor 14-amino acid peptide mediates endothelial hyperadhesivity and neutrophil adhesion by P-selectin-dependent mechanism

Related Peptides Products
Elcatonin

Elcatonin is a synthetic analog of eel calcitonin that increases bone density and inhibits bone resorption.

Pegmolesatide

Pegmolesatide is a synthetic peptide-based erythropoietic agent that may be used in studies related to anemia in chronic kidney disease.

Trofinetide

Trofinetide, a water-soluble analog of glycine-proline-glutamic acid (GPE), uses the unnatural amino acid 2-methylproline in place of the proline found in the natural compound, and works by enhancing synaptic activity, restoring synaptic structure, inhibiting the effects of inflammatory compounds in the brain, increasing antioxidant responses, reducing injury-induced cell death, and increasing central IGF-1 presence. It has neuroprotective activity and can be used in studies related to Rett syndrome.

Hemopressin (human, mouse)

Hemopressin is a natriuretic peptide derived from the α1 chain of hemoglobin, originally isolated from rat brain homogenates. Hemopressin is also an orally potent, selective inverse agonist at the CB1 cannabinoid receptor.Hemopressin has anti-injury sensory effects in models of inflammatory pain.

Trypsin Inhibitor (from Soybean)

Trypsin inhibitor is an alkaline polypeptide consisting of 58 amino acid residues with a pear shape throughout the molecule and a lysine activity center. It can compete with the activity center of many proteases for a lysyl group and inhibit their activities.

  Catalog
Abmole Inhibitor Catalog




Keywords: TRP-14, TRAP; SFLLRNPNDKYEPF; ThroMbin Receptor Agonist Peptide supplier, Peptides, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.