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Serotonin

Cat. No. M13360
Serotonin Structure
Synonym:

5-Hydroxytryptamine; 5-HT

Size Price Availability Quantity
5mg USD 100  USD100 In stock
10mg USD 150  USD150 In stock
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Quality Control & Documentation
Biological Activity

Serotonin is a monoamine neurotransmitter and endogenous 5-HT receptor agonist in CNS. Serotonin is also an inhibitor of catechin-o-methyltransferase (COMT) with a Ki value of 44 μM. Serotonin is also a natural product of animals.

Chemical Information
Molecular Weight 176.22
Formula C10H12N2O
CAS Number 50-67-9
Solubility (25°C) DMSO 80 mg/mL
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Thomas Dhenain, et al. Biochimie. Serotonin and orthodontic tooth movement

[2] Guillemette Fouquet, et al. Pharmacol Res. Serotonin, hematopoiesis and stem cells

[3] D J David, et al. Encephale. [The pharmacological basis of the serotonin system: Application to antidepressant response]

[4] Manfred Gthert. Pharmacol Rep. Serotonin discovery and stepwise disclosure of 5-HT receptor complexity over four decades. Part I. General background and discovery of serotonin as a basis for 5-HT receptor identification

[5] A Sirek, et al. Can Med Assoc J. Serotonin: a review

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Keywords: Serotonin, 5-Hydroxytryptamine; 5-HT supplier, 5-HT Receptor, inhibitors, activators


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