Free shipping on all orders over $ 500

Scopolamine hydrobromide

Cat. No. M3453
Scopolamine hydrobromide Structure
Synonym:

(-)-Scopolamine hydrobromide; Hyoscine hydrobromide; Scopine hydrobromide

Size Price Availability Quantity
50mg USD 40 In stock
100mg USD 50 In stock
500mg USD 135 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

Scopolamine is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 ± 4.3 nM. It is a tropane alkaloid compound with muscarinic antagonist effects. It is among the secondary metabolites of plants from Solanaceae (nightshade) family of plants, such as henbane, jimson weed and Angel’s Trumpets (Datura resp. Brugmansia spec.), and corkwood (Duboisia species). It exerts its effects by acting as a competitive antagonist at muscarinic acetylcholine receptors, specifically M1 receptors; it is thus classified as an anticholinergic, anti-muscarinic drug.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 384.26
Formula C17H21NO4.HBr
CAS Number 114-49-8
Purity 99.70%
Solubility DMSO 70 mg/mL
Storage at -20°C
Related AChR/AChE Products
Donepezil

Donepezil(E 2020) is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM, respectively.

Atropine

Competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.

Varenicline tartrate

Varenicline Tartrate is a nicotinic AChR partial agonist, used to treat nicotine addiction.

TD-4208

TD-4208 is a novel and potent muscarinic receptor antagonist that has a high affinity and long residence time at the M3 receptor, and demonstrates in vitro kinetic selectivity for M3 over M2 muscarinic receptor subtype and no meaningful off-target activity.

Tropicamide

Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist with IC50 of 8.0 nM.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Scopolamine hydrobromide, (-)-Scopolamine hydrobromide; Hyoscine hydrobromide; Scopine hydrobromide supplier, AChR/AChE, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.