Scopine Hcl salt is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||15 mg/mL in DMSO|
Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil.
Wang X, et al. Bioconjug Chem. 2014 Nov 19;25(11):2046-54. PMID: 25350514.
|Related Adrenergic Receptor Products|
Fenoterol is a β2 adrenoreceptor agonist with bronchodilator activity.
Norepinephrine is generally considered to be a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM.
Vibegron is a potent and selective beta 3 adrenergic receptor agonist.
L-755,507 is a very potent and selective β 3 partial agonist.
5-Iodotubercidin is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC.
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