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SCH23390

Cat. No. M9099
SCH23390 Structure
Synonym:

SCH 23390

Size Price Availability Quantity
10mg USD 145 In stock
25mg USD 330 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

SCH23390 is a potent dopamine receptor D1 antagonist with Ki values of 0.2 and 0.3 nM for the D1 and D5. SCH-23390 is also an agonist at 5-HT1C and 5-HT2C receptors in vitro (Ki values are 6.3 nM and 9.3 nM respectively). SCH23390 blocks quinpirole-induced Kir3 (GIRK) currents (EC50 = 268 nM) independently of receptors.

The repeated administration of SCH 23390 (0.05 mg/kg s.c., thrice daily for 21 days) enhances the steady-state density of dopamine D1 receptors in the striatum (+30%) and substantia nigra (+24%). This treatment also increases the production rates of dopamine D1 receptors in the striatum (+44%) and substantia nigra (+54%).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 287.78
Formula C17H18ClNO
CAS Number 87075-17-0
Purity >98%
Solubility DMSO
Storage at -20°C
Related Dopamine Receptor Products
MPTP HCl

MPTP hcl is a compound to the neurotoxin MPP+ which causes permanent symptoms of Parkinson's disease.

SKF38393 HCl

SKF38393 HCl is a selective D1 dopamine receptor agonist with IC50 of 110 nM.

SCH 23390 hydrochloride

SCH 23390 hydrochloride is a standard selective D 1-like antagonist; also 5-HT 2C and 5-HT 1C agonist and K ir3 channel blocker.

Sulpiride

Sulpiride is a dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.

rac-Rotigotine (Hydrochloride)

rac-Rotigotine Hcl is a high potency and selectivity agonist for D-2 receptor with Ki of 0.69 nM.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SCH23390, SCH 23390 supplier, Dopamine Receptor, inhibitors

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