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SB408124

Cat. No. M3324
SB408124 Structure
Size Price Availability Quantity
10mg USD 100 In stock
25mg USD 230 In stock
100mg USD 660 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

SB-408124 is a non-peptide antagonist selective for the orexin receptor subtype OX1, with around 70-fold selectivity for OX1 over OX2 receptors, and improved oral bioavailability compared to the older OX1 antagonist SB-334,867. It is used in scientific research into the function of orexinergic neurons in the body.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Male Wistar rats
Formulation SB-408124 is dissolved in saline.
Dosages 30 μg/10 μL
Administration Intracerebroventricularly (i.c.v.) injected into the lateral ventricle of the rat.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 356.37
Formula C19H18F2N4O
CAS Number 288150-92-5
Purity >99%
Solubility DMSO 30 mg/mL
Storage at -20°C
Related OX Receptor Products
SB-334867

SB-334867 is a selective non-peptide orexin OX1 receptor antagonist with a pKb value of 7.2.

TCS-1102

TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively).

MK-3697

MK-3697 is an isonicotinamide small molecule, acting as a potent and selective Orexin 2 receptor antagonist with Ki = 0.95 nM.

Suvorexant

Suvorexant (MK-4305) is a potent, selective and orally bioavailable antagonist of OX(1)R and OX(2)R for the treatment of insomnia.

MK-6096

MK-6096 is an orally bioavailable potent and selective reversible antagonist of OX(1)R and OX(2)R.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SB408124 supplier, OX Receptor, inhibitors

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