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SB 239063

Cat. No. M7582
SB 239063 Structure
Size Price Availability Quantity
5mg USD 120 In stock
10mg USD 200 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 368.4
Formula C20H21FN4O2
CAS Number 193551-21-2
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

HMGB1 Induces Secretion of Matrix Vesicles by Macrophages to Enhance Ectopic Mineralization.
Chen Q, et al. PLoS One. 2016 May 31;11(5):e0156686. PMID: 27243975.

Administration of SB239063, a potent p38 MAPK inhibitor, alleviates acute lung injury induced by intestinal ischemia reperfusion in rats associated with AQP4 downregulation.
Xiong LL, et al. Int Immunopharmacol. 2016 Sep;38:54-60. PMID: 27236300.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SB 239063 supplier, p38 MAPK, inhibitors

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