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Saxagliptin hydrate

Cat. No. M5952

Saxagliptin hydrate Structure

Synonym: BMS-477118 hydrate, Onglyza hydrate, BMS 477118 hydrate, BMS477118 hydrate

Size Price Availability Quantity
10mg USD 90 In stock
50mg USD 270 In stock
100mg USD 440 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Saxagliptin H2O is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 333.43
Formula C18H25N3O2.H2O
CAS Number 945667-22-1
Purity >99%
Solubility 66 mg/mL in DMSO
Storage at -20°C
References

Efficacy and tolerability of saxagliptin compared with glimepiride in elderly patients with type 2 diabetes: a randomized, controlled study (GENERATION).
Schernthaner G, et al. Diabetes Obes Metab. 2015 Jul;17(7):630-8. PMID: 25761977.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Saxagliptin hydrate, BMS-477118 hydrate, Onglyza hydrate, BMS 477118 hydrate, BMS477118 hydrate supplier, DPP-4, inhibitors

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