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Sarpogrelate HCl

Cat. No. M5951
Sarpogrelate HCl Structure
Synonym:

MCI-9042

Size Price Availability Quantity
10mg USD 90 In stock
50mg USD 270 In stock
100mg USD 360 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Sarpogrelate(MCI-9042) hydrochloride, a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 465.97
Formula C24H32ClNO6
CAS Number 135159-51-2
Purity >98%
Solubility 62 mg/mL in DMSO
Storage at -20°C
References

Beneficial Effects of Sarpogrelate and Rosuvastatin in High Fat Diet/Streptozotocin-Induced Nephropathy in Mice.
Kim DH, et al. PLoS One. 2016 Apr 20;11(4):e0153965. PMID: 27097221.

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Keywords: Sarpogrelate HCl, MCI-9042 supplier, 5-HT Receptor, inhibitors

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