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Sarafotoxin S6c

Cat. No. M9792
Sarafotoxin S6c Structure
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1mg USD 900  USD900 In stock
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Biological Activity

Sarafotoxin S6c is a highly selective ETB endothelin receptor agonist (Ki values are 0.29 and 28000 nM at ETB and ETA receptors respectively).

Chemical Information
Molecular Weight 2516
Formula C103H147N27O37S5
CAS Number 121695-87-2
Solubility (25°C) Water 1 mg/mL
Storage -20°C, dry, sealed, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] N Miasiro, et al. J Cardiovasc Pharmacol. Distinct endothelin-B receptors mediate the effects of sarafotoxin S6c and IRL1620 in the ileum

[2] G Matsuo, et al. J Pharmacol Exp Ther. Effects of sarafotoxin S6c on antidiuresis and norepinephrine overflow induced by stimulation of renal nerves in anesthetized dogs

[3] D L Williams Jr, et al. Biochem Biophys Res Commun. Sarafotoxin S6c: an agonist which distinguishes between endothelin receptor subtypes

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Atrial Natriuretic Peptide (ANP) (1-28), rat

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[Asn18] Endothelin-1, human

[Asn18] Endothelin-1, human is a peptide.

[Lys4] Sarafotoxin S6c

[Lys4] Sarafotoxin S6c, a sarafotoxin analogue, is a potent and partial agonist of endothelin receptor.

[Ala2] Endothelin-3, human

[Ala2] Endothelin-3, human is a linear analog of endothelin-3 (ET-3) where substitution of Ala for Cys residues.

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