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SAR7334

Cat. No. M9089
SAR7334 Structure
Size Price Availability
10mg USD 470 1-2 Weeks
50mg USD 1000 1-2 Weeks
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

SAR7334 is a TRPC6 inhibitor, and used for treat the fibrotic disorders, such as focal segmental glomerulosclerosis, skeletal muscle dysfunction. SAR7334 inhibited TRPC6, TRPC3 and TRPC7-mediated Ca(2+) influx into cells with IC50 s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca(2+) entry was not affected.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 367.87
Formula C21H22ClN3O
CAS Number 1333210-07-3
Purity >98%
Solubility DMSO: ≥ 100 mg/mL
Storage at -20°C
References

Pharmacological Characterization of the Native Store-Operated Calcium Channels of Cortical Neurons from Embryonic Mouse Brain.
Chauvet S, et al. Front Pharmacol. 2016 Dec 12;7:486. PMID: 28018223.

Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels.
Maier T, et al. Br J Pharmacol. 2015 Jul;172(14):3650-60. PMID: 25847402.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SAR7334 supplier, inhibitors

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