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Sapienic acid sodium

Cat. No. M21218
Sapienic acid sodium Structure
Size Price Availability
5mg USD 120  USD150 4-7 Days
10mg USD 168  USD210 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Sapienic acid sodium is a fatty acid commonly found on the skin and in mucosa. Sapienic acid sodium is active against Streptococcus sanguinis, Streptococcus mitis and Fusobacterium nucleatum with MBC values of 31.3 μg/mL, 375.0 μg/mL and 93.8 μg/mL, respectively. Sapienic acid sodium has variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 276.39
Formula C16H29NaO2
CAS Number 217477-25-3
Purity >98%
Solubility Ethanol 30 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Carol L Fischer, et al. Antimicrob Agents Chemother. Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteria

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