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Samuraciclib hydrochloride

Cat. No. M10886
Samuraciclib hydrochloride Structure
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Biological Activity

Samuraciclib (ICEC0942, CT7001) is a novel oral CDK7 inhibitor with an IC50 of 40 nM. It has IC50 values for other CDK proteins such as CDK1, CDK2, CDK5 and CDK9 as 45, 15, 230 and 30 times higher than that of CDK7 IC50, respectively. ICEC0942 (CT7001) promotes cell cycle blocking and apoptosis.

Chemical Information
Molecular Weight 430.98
Formula C22H31ClN6O
CAS Number 1805789-54-1
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Qijun Pan, et al. Org Biomol Chem. Copper-catalyzed three-component reaction of arylhydrazine hydrochloride, DABSO, and NFSI for the synthesis of arenesulfonyl fluorides

[2] Mahmut Atum, et al. Ideggyogy Sz. Delirium due to the use of topical cyclopentolate hydrochloride

[3] No authors listed. Carteolol

[4] S HIFT, et al. Wien Med Wochenschr. [Prothipendyl-hydrochloride, a new neuroleptic]

[5] S Groszkowski, et al. Pol J Pharmacol Pharm. 1-Haloacylpiperazines

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  Catalog
Abmole Inhibitor Catalog




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