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SAM-315

Cat. No. M9584
SAM-315 Structure
Synonym:

WAY-255315

Size Price Availability
50mg USD 900  USD900 4-7 Days
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Quality Control & Documentation
Biological Activity

SAM-31 (WAY-255315) is selective 5-Hydroxytryptamine-6 antagonists.

Chemical Information
Molecular Weight 392.47
Formula C21H20N4O2S
CAS Number 744218-85-7
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kevin G Liu, et al. 5-Piperazinyl-3-sulfonylindazoles as potent and selective 5-hydroxytryptamine-6 antagonists

[2] P Chiba, et al. S-adenosylmethionine metabolism in HL-60 cells: effect of cell cycle and differentiation

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  Catalog
Abmole Inhibitor Catalog




Keywords: SAM-315, WAY-255315 supplier, 5-HT Receptor, inhibitors, activators


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