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Saikogenin A

Cat. No. M39064
Saikogenin A Structure
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5mg USD 720  USD720 In stock
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Quality Control & Documentation
Biological Activity

Saikogenin A, extracted from a Chinese herbal plant called Tsai-Fu, is a dipeptidyl peptidase-IV (DPP-IV) inhibitor.

Chemical Information
Molecular Weight 472.7
Formula C30H48O4
CAS Number 5092-09-1
Form Solid
Solubility (25°C) DMSO 25 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Biao Zeng et al. Nat Prod Res. A new triterpenoid saponin from Clinopodium chinense (Benth.) O. Kuntze

[2] S Shibata et al. Chem Pharm Bull (Tokyo). The chemical studies on oriental plant drugs. XV. On the constituents of Bupleurum Spp. (2). The structure of saikogenin A, a sapogenin of Bupleurum falcatum L

[3] S Shibata et al. Tetrahedron Lett. The structure of saikogenin A, a sapogenin of Bupleurum species

[4] J T Cheng et al. Biochem Pharmacol. Anti-inflammatory effect of saikogenin A

[5] Y Kumazawa et al. Int J Immunopharmacol. Protective effect of saikosaponin A, saikosaponin D and saikogenin D against Pseudomonas aeruginosa infection in mice

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Keywords: Saikogenin A supplier, Dipeptidyl Peptidase, inhibitors, activators


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