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SA 4503 dihydrochloride

Cat. No. M2991
SA 4503 dihydrochloride Structure
Synonym:

AGY94806 dihydrochloride; Cutamesine dihydrochloride

Size Price Availability Quantity
5mg USD 90  USD90 In stock
10mg USD 145  USD145 In stock
50mg USD 600  USD600 In stock
100mg USD 820  USD820 In stock
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Quality Control & Documentation
Biological Activity

SA 4503 is a novel and selective opioid sigma1 receptor agonist with IC50 of 17.4 nM.

Chemical Information
Molecular Weight 441.43
Formula C23H32N2O2.2HCl
CAS Number 165377-44-6
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ayla Mansur, et al. Characterization of 3 PET Tracers for Quantification of Mitochondrial and Synaptic Function in Healthy Human Brain: 18 F-BCPP-EF, 11 C-SA-4503, and 11 C-UCB-J

[2] Kelli R Rodvelt, et al. The sigma receptor agonist SA4503 both attenuates and enhances the effects of methamphetamine

[3] Kelli R Rodvelt, et al. SA 4503 attenuates cocaine-induced hyperactivity and enhances methamphetamine substitution for a cocaine discriminative stimulus

[4] Guillaume Lucas, et al. Further evidence for an antidepressant potential of the selective sigma1 agonist SA 4503: electrophysiological, morphological and behavioural studies

[5] Dayong Wang, et al. Role of N-methyl-D-aspartate receptors in antidepressant-like effects of sigma 1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride (SA-4503) in olfactory bulbectomized rats

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Keywords: SA 4503 dihydrochloride, AGY94806 dihydrochloride; Cutamesine dihydrochloride supplier, Sigma Receptor, inhibitors, activators


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