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(S)-crizotinib

Cat. No. M2350

(S)-crizotinib Structure
Size Price Availability
5mg USD 100 Out of stock
25mg USD 260 Out of stock
50mg USD 420 Out of stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

(S)-crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition, induced an increase in DNA single-strand breaks, activated DNA repair in human colon carcinoma cells, and effectively suppressed tumour growth in animal models. Over all, (S)-crizotinib is an attractive chemical entity for further pre-clinical evaluation, and small-molecule inhibitors of MTH1 in general as a promising novel class of anticancer agents.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 450.34
Formula C21H22Cl2FN5O
CAS Number 1374356-45-2
Purity >99%
Solubility DMSO
Storage at -20°C
  Catalog
Abmole Inhibitor Catalog 2017




Keywords: (S)-crizotinib supplier, MTH1, inhibitors

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