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S-Adenosylhomocysteine

Cat. No. M9611
S-Adenosylhomocysteine Structure
Synonym:

SAH; AdoHcy

Size Price Availability Quantity
5mg USD 58  USD58 In stock
10mg USD 90  USD90 In stock
25mg USD 150  USD150 In stock
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Quality Control & Documentation
Biological Activity

S-Adenosylhomocysteine, an intermediate in the synthesis of cysteine and adenosine, is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM.

Product Citations
Chemical Information
Molecular Weight 384.41
Formula C14H20N6O5S
CAS Number 979-92-0
Solubility (25°C) DMSO ≥ 10 mg/mL
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Madan Kumar Arumugam, et al. Elevated S-adenosylhomocysteine induces adipocyte dysfunction to promote alcohol-associated liver steatosis

[2] Hitoshi Ouchi, et al. S-Adenosylhomocysteine Analogue of a Fairy Chemical, Imidazole-4-carboxamide, as its Metabolite in Rice and Yeast and Synthetic Investigations of Related Compounds

[3] Joy Xin Wang, et al. Riboswitches that sense S-adenosylmethionine and S-adenosylhomocysteine

[4] Conrad Wagner, et al. S-Adenosylhomocysteine: a better indicator of vascular disease than homocysteine?

[5] Doris Kloor, et al. S-Adenosylhomocysteine hydrolase as a target for intracellular adenosine action

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STM2120

STM2120 is a METTL3-METTL14 inhibitor with an IC50 of 64.5 μM.

7OQL

7OQL is a selective METTL3 inhibitor (IC50=0.054 µM).

STC-15

STC-15 is a METTL3 inhibitor used in the study of proliferative diseases such as cancer and autoimmune diseases.

UZH2 

UZH2 is a potent and selective METTL3 inhibitor with an IC50 value of 5 nM.

  Catalog
Abmole Inhibitor Catalog




Keywords: S-Adenosylhomocysteine, SAH; AdoHcy supplier, METTL3, inhibitors, activators


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