S-Adenosylhomocysteine, an intermediate in the synthesis of cysteine and adenosine, is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM.
Mol Nutr Food Res. 2023 Feb 3;e2101052.
Oxidative Stress Mediated by N6‐Methyladenosine Methylation Contributes to High‐Fat Diet Induced Male Reproductive Dysfunction
S-Adenosylhomocysteine purchased from AbMole
Molecular Weight | 384.41 |
Formula | C14H20N6O5S |
CAS Number | 979-92-0 |
Solubility (25°C) | DMSO ≥ 10 mg/mL |
Storage | -20°C, protect from light, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] Joy Xin Wang, et al. Riboswitches that sense S-adenosylmethionine and S-adenosylhomocysteine
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