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Ruxolitinib phosphate

Cat. No. M5944
Ruxolitinib phosphate Structure
Size Price Availability Quantity
5mg USD 80 In stock
50mg USD 300 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Ruxolitinib phosphate(INCB018424 phosphate) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 404.36
Formula C17H21N6O4P
CAS Number 1092939-17-7
Purity >99%
Solubility 31 mg/mL in DMSO
Storage at -20°C
References

Pharmacokinetics and pharmacodynamics of orally administered ruxolitinib (INCB018424 phosphate) in renal and hepatic impairment patients.
Chen X, et al. Clin Pharmacol Drug Dev. 2014 Jan;3(1):34-42. PMID: 27128228.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Ruxolitinib phosphate supplier, JAK, inhibitors

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