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Ruxolitinib phosphate

Cat. No. M5944
Ruxolitinib phosphate Structure
Synonym:

INCB018424 phosphate; INCB 018424 phosphate; INCB-018424 phosphate; Ruxolitinib

Size Price Availability Quantity
5mg USD 40  USD40 In stock
10mg USD 60  USD60 In stock
25mg USD 90  USD90 In stock
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Quality Control & Documentation
Biological Activity

Ruxolitinib phosphate(INCB018424 phosphate) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3.

Product Citations
Chemical Information
Molecular Weight 404.36
Formula C17H21N6O4P
CAS Number 1092939-17-7
Solubility (25°C) DMSO ≥ 30 mg/mL
Water 8.2 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chen X, et al. Clin Pharmacol Drug Dev. Pharmacokinetics and pharmacodynamics of orally administered ruxolitinib (INCB018424 phosphate) in renal and hepatic impairment patients.

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Keywords: Ruxolitinib phosphate, INCB018424 phosphate; INCB 018424 phosphate; INCB-018424 phosphate; Ruxolitinib supplier, JAK, inhibitors, activators


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