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Rufinamide

Cat. No. M5943

Rufinamide Structure

Synonym: CGP 33101

Size Price Availability Quantity
10mg USD 70 In stock
50mg USD 220 In stock
100mg USD 350 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Rufinamide is a voltage-gated sodium channel blocker, used an anticonvulsant medication.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 238.19
Formula C10H8F2N4O
CAS Number 106308-44-5
Purity >99%
Solubility 18 mg/mL warmed in DMSO
Storage at -20°C
References

Current role of rufinamide in the treatment of childhood epilepsy: literature review and treatment guidelines.
Coppola G, et al. Eur J Paediatr Neurol. 2014 Nov;18(6):685-90. PMID: 24929673.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Rufinamide, CGP 33101 supplier, Sodium Channel, inhibitors

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