Free shipping on all orders over $ 500

RU 58841

Cat. No. M2344

RU 58841 Structure
Size Price Availability Quantity
10mg USD 280 In stock
50mg USD 735 In stock
Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

RU 58841 is a specific androgen receptor antagonist or anti-androgen used as a topical treatment for acne, androgenetic alopecia and hirsutism. RU 58841 displays high affinity for the hamster prostate and flank organ (F.O.) androgen receptors. In vivo, when topically applied, it exerts a potent dose-dependent regression of F.O. area at a dose as low as 1 microgram/animal while being devoid of antiandrogenic activity on deep accessory sex organs and of any effect on testosterone level up to 100 micrograms/animal. RU 58841 has a dramatic effect on hair regrowth.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 369.34
Formula C17H18F3N3O3
CAS Number 154992-24-2
Purity >99%
Solubility DMSO
Storage at -20°C
References

RU 58841, a new specific topical antiandrogen: a candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism.
Battmann T, et al. J Steroid Biochem Mol Biol. 1994 Jan;48(1):55-60. PMID: 8136306.

Related Androgen Receptor Products
Lubiprostone

Lubiprostone is an orally active prostone that locally and selectively activates ClC-2 chloride channels to enhance the intestinal fluid secretion without altering the serum electrolyte levels.

Nandrolone phenylpropionate

Nandrolone phenylpropionate (NPP) is an anabolic-androgenic steroid. The low androgenicity and enhanced anabolic activity of NPP has shown to positively influence calcium metabolism and to increase bone mass in osteoporosis.

ChlordehydroMethyl Testosterone

Testosterone is normally present in the circulation of both men and women. Due to the dynamic regulation of endogenous testosterone production, including the acute effects of competition and exercise, testosterone concentrations may vary considerably within and among individuals.

Testosterone phenylpropionate

Testosterone phenylpropionate is a synthetic anabolic-androgenic steroid (AAS) and an androgen ester.

Testosterone isocaproate

Testosterone Isocaproate help in increasing the body weight and will also help in gaining the strength and also help in losing fat in the body and gives an increase in libido, red blood cells, stamina and quick recovery after heavy training.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: RU 58841 supplier, Androgen Receptor, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.