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RS102895

Cat. No. M11028
RS102895  Structure
Size Price Availability Quantity
10mg USD 200  USD200 In stock
25mg USD 400  USD400 In stock
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Quality Control & Documentation
Biological Activity

RS102895 is a potent CCR2 antagonist,IC50 The value is 360 nM .

Chemical Information
Molecular Weight 390.4
Formula C21H21F3N2O2
CAS Number 300815-41-2
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jingzhou Wang, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. [RS102895 inhibits the proliferation, invasion, and migration of PC-3 prostate cancer cells by blocking CCL2/CCR2 pathway]

[2] Swati Singh, et al. Front Cell Neurosci. CCR2 Inhibition Reduces Neurotoxic Microglia Activation Phenotype After Japanese Encephalitis Viral Infection

[3] Leyuan Xu, et al. J Am Soc Nephrol. Tubular GM-CSF Promotes Late MCP-1/CCR2-Mediated Fibrosis and Inflammation after Ischemia/Reperfusion Injury

[4] Su Jin Seok, et al. Nephrol Dial Transplant. Blockade of CCL2/CCR2 signalling ameliorates diabetic nephropathy in db/db mice

[5] Leah A Mitchell, et al. Int Immunopharmacol. Optimized dosing of a CCR2 antagonist for amplification of vaccine immunity

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