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Roxatidine Acetate HCl

Cat. No. M5942
Roxatidine Acetate HCl Structure
Synonym:

HOE 760

Size Price Availability Quantity
100mg USD 100  USD100 In stock
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Quality Control & Documentation
Biological Activity

Roxatidine Acetate HCl is a specific and competitive histamin H2-receptor antagonist, with IC50 of 3.2 μM, inhibits gastric acid secretion and ulcer formation.

Chemical Information
Molecular Weight 384.9
Formula C19H28N2O4.HCl
CAS Number 93793-83-0
Solubility (25°C) 77 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Nakamura H, et al. Drug Metab Pharmacokinet. Pharmacokinetics of the H(2) blocker roxatidine acetate hydrochloride in pediatric patients, in comparison with healthy adult volunteers.

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Keywords: Roxatidine Acetate HCl, HOE 760 supplier, Histamine Receptor, inhibitors, activators


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