Free shipping on all orders over $ 500

Ropinirole hydrochloride

Cat. No. M2987
Ropinirole hydrochloride Structure
Synonym:

SKF 101468 hydrochloride

Size Price Availability Quantity
50mg USD 80  USD80 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Ropinirole a selective dopamine D2 receptors inhibitor with IC50 of 29 nM.

Chemical Information
Molecular Weight 296.84
Formula C16H24N2O.HCl
CAS Number 91374-20-8
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hideyuki Okano, et al. Ropinirole, a New ALS Drug Candidate Developed Using iPSCs

[2] Shinichi Takahashi, et al. Ropinirole Hydrochloride for ALS

[3] Shinichi Takahashi, et al. Ropinirole Hydrochloride, a Candidate Drug for ALS Treatment

[4] Satoru Morimoto, et al. Ropinirole hydrochloride remedy for amyotrophic lateral sclerosis - Protocol for a randomized, double-blind, placebo-controlled, single-center, and open-label continuation phase I/IIa clinical trial (ROPALS trial)

[5] Hiroyuki Arai, et al. Pharmacological profiles and clinical effects of ropinirole hydrochloride (ReQuip)

Related Dopamine Receptor Products
Cyclo(glycyl-L-leucyl)

Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates dopamine (DA) receptors and attenuates dopaminergic supersensitivity.

Onzigolide

Onzigolide (BIM-23A760), a chimeric dopamine-somatostatin compound, shows potent agonist activity at both DA type 2 (D2R) and SST type 2 (SSTR2) receptors.

CVL-871

CVL-871 is a partial agonist at dopamine D1/5 receptors and may be used in dementia-related studies.

Paliperidone palmitate

Paliperidone palmitate is the ester precursor compound of Paliperidone, a potent dopamine antagonist and 5-HT2A antagonist. Paliperidone is a potent dopamine antagonist and 5-HT2A antagonist.

Melevodopa

Melevodopaa is an oral precursor compound to Levodopa that enters the body and can pass through the gut and blood-brain barrier into the brain. In the brain, Melevodopa is converted to dopamine, which increases dopamine levels in the brain and can be used in studies related to Parkinson's disease.

  Catalog
Abmole Inhibitor Catalog




Keywords: Ropinirole hydrochloride, SKF 101468 hydrochloride supplier, Dopamine Receptor, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.