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Rocuronium bromide

Cat. No. M2268
Rocuronium bromide Structure
Synonym:

Zemuron, Esmeron

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 44  USD44 In stock
50mg USD 66  USD66 In stock
100mg USD 90  USD90 In stock
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Quality Control & Documentation
Biological Activity

Rocuronium bromide (Zemuron, Esmeron) is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant.

Chemical Information
Molecular Weight 609.68
Formula C32H53N2O4.Br
CAS Number 119302-91-9
Solubility (25°C) DMSO 100 mg/mL
Water 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kaoru Suzuki, et al. Intravenous infusion of rocuronium bromide prolongs emergence from propofol anesthesia in rats

[2] Bertrand Guihard, et al. Effect of Rocuronium vs Succinylcholine on Endotracheal Intubation Success Rate Among Patients Undergoing Out-of-Hospital Rapid Sequence Intubation: A Randomized Clinical Trial

[3] Tomonori Takazawa, et al. Sugammadex and rocuronium-induced anaphylaxis

[4] John F Bebawy. Rocuronium bromide

[5] K S Khuenl-Brady, et al. Clinical pharmacokinetics of rocuronium bromide

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Keywords: Rocuronium bromide, Zemuron, Esmeron supplier, AChR/AChE, inhibitors, activators


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