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Ro 31-0432

Cat. No. M8133
Ro 31-0432 Structure
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Biological Activity

Protein kinase C (PKC) inhibitor; membrane-derived PKC inhibitor.

Chemical Information
Molecular Weight 489.01
Formula C28H28N4O2 · HCl
CAS Number 145333-02-4
Solubility (25°C) DMSO: 5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wei Yu, et al. Antiscalants in RO membrane scaling control

[2] Eduardo Coutinho de Paula, et al. Extending the life-cycle of reverse osmosis membranes: A review

[3] Chie Kohchi, et al. ROS and innate immunity

[4] F Franceschini, et al. Anti-Ro/SSA and La/SSB antibodies

[5] P Dieter, et al. RO 31-8220 and RO 31-7549 show improved selectivity for protein kinase C over staurosporine in macrophages

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