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Rizatriptan Benzoate

Cat. No. M5938
Rizatriptan Benzoate Structure
Synonym:

MK-462 Benzoate

Size Price Availability Quantity
10mg USD 75 In stock
50mg USD 250 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Rizatriptan Benzoate is an agonist at serotonin 5-HT1B and 5-HT1D receptors, used to treat acute migraine attacks.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 391.47
Formula C22H25N5O2
CAS Number 145202-66-0
Purity >99%
Solubility 46 mg/mL in water
Storage at -20°C
References

Formulation of rizatriptan benzoate fast dissolving buccal films by emulsion evaporation technique.
Vidyadhara S, et al. Int J Pharm Investig. 2015 Apr-Jun;5(2):101-6. PMID: 25838995.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Rizatriptan Benzoate, MK-462 Benzoate supplier, 5-HT Receptor, inhibitors

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